This scientific article explores the intricate relationship between geography and economics in shaping regional and urban development. It discusses the impact of recent global uncertainties, such as climatic disruptions and geopolitical conflicts, on the spatial-economic landscape. The authors propose a new governance model that emphasizes adaptability, collaboration, and innovation to manage these challenges. The article also introduces a “Pentagon” model to assess the convergence of spatial systems and highlights key topics like regional uncertainty management, digitalization, and the concept of the 15-minute city.